Electrochemical Labeling and Detection of Dna: Recent Advances

Labeled DNA probes have got enormous amounts of applications in various fields such as DNA sequencing and detection of mutations. Analysis of large number of samples in short period of time is always desirable. Methods of labeling of DNA are divided into three categories i.e. radiolabeling, fluorescence labeling and redox or electrochemical labeling. Though sensitive, use of radioactive labels is hazardous and associated with several regulatory issues. Fluorescent DNA probes have got drawback of expensive reagents and instrumentation. Electrochemical labeling is booming these days because of its simplicity, cost effectiveness and ease of miniaturation. This review article puts light on different techniques of DNA labeling and their detection, recent techniques of electrochemical labeling and its advantages.